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I. Structure-function analysis of the mechanosensitive channel of large conductance. II. Design of novel magnetic materials using crystal engineering

Citation

Maurer, Joshua Ahab (2003) I. Structure-function analysis of the mechanosensitive channel of large conductance. II. Design of novel magnetic materials using crystal engineering. Dissertation (Ph.D.), California Institute of Technology. http://resolver.caltech.edu/CaltechETD:etd-10202002-002307

Abstract

The work presented here encompasses two distinct areas, with the first section addressing structure-function relationships in the mechanosensitive channel of large conductance (MscL) from bacteria. A high-throughput fluorescent screening technique has been developed for the E. coli homologue of MscL. This technique has been applied to a large library of random E. coli MscL mutations to provide insights into channel function. Additionally, attempts have been made to characterize the functionally important regions of MscL and comparisons have been made between the E. coli and M. tuberculosis homologues of MscL. The second section addresses the design of novel magnetic materials. The guanidinium sulfonate ?Ward lattice? from crystal engineering has been used to develop a new family of frustrated magnetic materials.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:; E. coli; ion-channel; M. tuberculosis; mechanosensitive channel of large conductance; Molecular Magnetism; MscL; salen
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Dougherty, Dennis A.
Thesis Committee:
  • Grubbs, Robert H. (chair)
  • Tirrell, David A.
  • Dougherty, Dennis A.
  • Lester, Henry A.
  • Barton, Jacqueline K.
  • Davis, Mark E.
Defense Date:2 October 2002
Author Email:jmaurer (AT) caltech.edu
Record Number:CaltechETD:etd-10202002-002307
Persistent URL:http://resolver.caltech.edu/CaltechETD:etd-10202002-002307
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:4188
Collection:CaltechTHESIS
Deposited By: Imported from ETD-db
Deposited On:21 Oct 2002
Last Modified:26 Dec 2012 03:06

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