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Computational Microscopy: Turning Megapixels into Gigapixels


Horstmeyer, Roarke William (2016) Computational Microscopy: Turning Megapixels into Gigapixels. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/Z95Q4T1W.


The layout of a typical optical microscope has remained effectively unchanged over the past century. Besides the widespread adoption of digital focal plane arrays, relatively few innovations have helped improve standard imaging with bright-field microscopes. This thesis presents a new microscope imaging method, termed Fourier ptychography, which uses an LED to provide variable sample illumination and post-processing algorithms to recover useful sample information. Examples include increasing the resolution of megapixel-scale images to one gigapixel, measuring quantitative phase, achieving oil-immersion quality resolution without an immersion medium, and recovering complex three dimensional sample structure.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:Computational imaging, biophotonics, microscopy, optics
Degree Grantor:California Institute of Technology
Division:Engineering and Applied Science
Major Option:Electrical Engineering
Awards:Everhart Distinguished Graduate Student Lecturer Award, 2015. Charles and Ellen Wilts Prize, 2016.
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Yang, Changhuei
Thesis Committee:
  • Yang, Changhuei (chair)
  • Tropp, Joel A.
  • Vaidyanathan, P. P.
  • Hassibi, Babak
  • Zheng, Guoan
Defense Date:15 October 2015
Non-Caltech Author Email:roarke.horstmeyer (AT)
Funding AgencyGrant Number
National Institutes of Health1DP2OD007307-01
National Institutes of HealthR01AI096226-01
Record Number:CaltechTHESIS:10202015-173005082
Persistent URL:
Horstmeyer, Roarke William0000-0002-2480-9141
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:9231
Deposited By: Roarke Horstmeyer
Deposited On:12 Nov 2015 22:11
Last Modified:08 Nov 2023 18:41

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