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Evolution and Expression at the 68C Glue Gene Cluster of Drosophila


Martin, Christopher Hayes (1988) Evolution and Expression at the 68C Glue Gene Cluster of Drosophila. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/p2n6-q185.


This thesis describes investigations on the evolution of a region containing a cluster of three glue genes located at chromosomal site 68C in the Drosophila melanogaster genome. These studies have used a set of five closely related Drosophila species, all members of the melanogaster species subgroup. The first chapter serves as an introduction and summarizes this work. The second chapter describes the initial characterization of the glue gene clusters and the surrounding regions in the five Drosophila species. The third chapter describes the characterization at the sequence level of the boundary that was found between adjacent blocks of rapidly and slowly evolving sequences located at the 68C glue gene cluster. The fourth chapter describes the evolution of the largest of the three glue genes in the 68C glue gene cluster: Sgs-3. Together, these studies reveal that this region of the genome is evolving as a mosaic, with adjacent regions evolving at different rates and in very different ways.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:Biology
Degree Grantor:California Institute of Technology
Major Option:Biology
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Meyerowitz, Elliot M.
Thesis Committee:
  • Meyerowitz, Elliot M. (chair)
  • Emr, Scott D.
  • Rothenberg, Ellen V.
  • Abelson, John N.
  • Tanouye, Mark
Defense Date:7 December 1987
Record Number:CaltechTHESIS:02152013-142530976
Persistent URL:
Related URLs:
URLURL TypeDescription adapted for Chapter 1. adapted for Chapter 2. adapted for Chapter 3. adapted for Chapter 4.
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7481
Deposited On:15 Feb 2013 22:59
Last Modified:16 Apr 2021 22:17

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