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Investigations of Different Methods to Promote Drug Mixing in the Eye


Huang, Jinglin Alice (2020) Investigations of Different Methods to Promote Drug Mixing in the Eye. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/741T-MN38.


Age-related macular degeneration (AMD) is the leading cause of central vision loss in the developed world. In the case of wet AMD, it can be managed through serial intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) agents. However, sometimes the treatment is ineffective. Given that half-life time of the drug is limited, one possible cause of the ineffective treatment is inefficient drug mixing in the eye. Here, we focus on the understanding of drug mixing in vitreous chamber and parameters that could potentially influence mixing profiles. Both movement-driven method and thermal-driven method are explored. The in-vitro study outcomes will not only be useful for achieving fundamental understandings of fluid dynamics in the eye, but also helpful in developing a better strategy for intravitreal injection and improving the quality of care for patients.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:age related macular degeneration, drug mixing, thermally induced convection
Degree Grantor:California Institute of Technology
Division:Engineering and Applied Science
Major Option:Medical Engineering
Awards:Advocating Change Together (ACT) Award, 2017. Caltech Three Minute Thesis (3MT) competition, 2018: 3rd Place.
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Gharib, Morteza
Group:Resnick Sustainability Institute, 3MT Competition (Caltech)
Thesis Committee:
  • Tai, Yu-Chong (chair)
  • Gao, Wei
  • Petrasek, Danny
  • Schwartz, Daniel M.
  • Gharib, Morteza
Defense Date:25 September 2019
Non-Caltech Author Email:alicehuang0904 (AT)
Record Number:CaltechTHESIS:12122019-162434400
Persistent URL:
Huang, Jinglin Alice0000-0003-0760-4950
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13608
Deposited By: Jinglin Huang
Deposited On:16 Dec 2019 19:32
Last Modified:09 Aug 2022 16:47

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