Abstract
A physical lens is limited in its ability to capture an image that is both high- resolution and wide-field due to aberrations even with a sophisticated lens design. This thesis explores computational methods that expand on the recently developed Fourier ptychographic microscopy (FPM) to overcome the physical limitations. New algorithms and imaging methods extend the computational aberration correction to more general imaging modalities including fluorescence microscopy and incoherent bright-field imaging so as to allow even a crude lens to perform like an ideal lens. This paradigm shift from the lens design to computational algorithms democratizes high-resolution imaging by making it easier to use and less complicated to build.
Item Type: | Thesis (Dissertation (Ph.D.)) |
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Subject Keywords: | Fourier ptychographic microscopy, FPM, computational aberration correction, deconvolution, phase retrieval, retinal imaging, wide field of view imaging |
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Degree Grantor: | California Institute of Technology |
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Division: | Engineering and Applied Science |
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Major Option: | Electrical Engineering |
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Thesis Availability: | Public (worldwide access) |
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Research Advisor(s): | |
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Thesis Committee: | - Wang, Lihong (chair)
- Yang, Changhuei
- Shapiro, Mikhail G.
- Hassibi, Babak
- Zheng, Guoan
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Defense Date: | 1 May 2019 |
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Non-Caltech Author Email: | jaebum (AT) alumni.caltech.edu |
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Funders: | Funding Agency | Grant Number |
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NIH | R21 EY026228A | NIH | R01 AI096226 | Caltech Innovation Initiative (CI2) Research Grant. | 25570015 | NIH | 1DP2OD007307 | Department of Defense (DOD) | W81XWH-09-1-0050 |
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Record Number: | CaltechTHESIS:05202019-151055724 |
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Persistent URL: | https://resolver.caltech.edu/CaltechTHESIS:05202019-151055724 |
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DOI: | 10.7907/8W3A-HE02 |
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Related URLs: | |
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ORCID: | |
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Default Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. |
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ID Code: | 11525 |
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Collection: | CaltechTHESIS |
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Deposited By: |
Jaebum Chung
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Deposited On: | 23 May 2019 16:09 |
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Last Modified: | 08 Nov 2023 18:41 |
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