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The Diffusion of Ions in Agar Gel Suspensions of Red Blood Cells


Chilcote, Dennis Don (1971) The Diffusion of Ions in Agar Gel Suspensions of Red Blood Cells. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/RT04-RZ27.


A method was developed for measuring the self-diffusion coefficient of solutes in agar gel suspensions of red cells. The purpose was to investigate the influence of the red cell on the diffusion of ions which are important in blood solute transport.

The capillary diffusion method was employed. The diffusion coefficient was calculated from the initial and final concentration of tracer in the capillary. The results are discussed in terms of a modified Maxwell equation for the average conductivity in a granular medium in which a discontinuous boundary condition is employed to account for the observed partition coefficients.

The results indicate the ration of the diffusivity of solute in the red cell suspension to that in the suspending medium varies considerably with the ion. This ratio is greater for sodium than for chloride over the range of red cell volume fractions investigated. An augmented diffusional mechanism for bicarbonate appears to exist in the red cell suspension. Depleting the intracellular ATP has little effect on the diffusion of sodium in the red cell suspension.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:Chemical Engineering
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemical Engineering
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Friedlander, Sheldon K.
Thesis Committee:
  • Unknown, Unknown
Defense Date:18 December 1969
Funding AgencyGrant Number
Public Health ServiceUNSPECIFIED
Record Number:CaltechTHESIS:02142018-090205487
Persistent URL:
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10721
Deposited By: Benjamin Perez
Deposited On:14 Feb 2018 18:04
Last Modified:21 Dec 2019 01:25

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