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Integration of dye lasers and microfluidics for biochemical analysis

Citation

Chen, Yan (2009) Integration of dye lasers and microfluidics for biochemical analysis. Dissertation (Ph.D.), California Institute of Technology. http://resolver.caltech.edu/CaltechETD:etd-07202008-164745

Abstract

This dissertation describes the study of two important aspects of integration in microfluidics: optics and biochemistry. In optics integration, two types of miniaturized dye lasers, namely the solid-state polymer dye lasers and optofluidic dye lasers were demonstrated. Both of the dye lasers possess a resonant cavity with circular grating geometry, and they are suitable to serve as low-threshold, surface-emitting coherent light source in microfluidic networks. The mass production and large scale fabrication of such low-cost dye laser arrays can be realized by the well developed nanoimprint and soft lithography, making this technology attractive for various biochemical applications. In biochemistry integration, a microfluidic system was developed to fully utilize the complexity of microfluidic circuits to process single cells and extract gene expression information in a parallel manner. The work presented here explored both the optics and biochemistry integration in microfluidics, which are the key issues for further development of complete “lab-on-a-chip” systems.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:circular grating; dye laser; microfluidics; nanoimprint
Degree Grantor:California Institute of Technology
Division:Engineering and Applied Science
Major Option:Bioengineering
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Scherer, Axel
Thesis Committee:
  • Scherer, Axel (chair)
  • Yang, Changhuei
  • Guo, Chin-Lin
  • Painter, Oskar J.
  • Tai, Yu-Chong
Defense Date:18 July 2008
Record Number:CaltechETD:etd-07202008-164745
Persistent URL:http://resolver.caltech.edu/CaltechETD:etd-07202008-164745
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:5238
Collection:CaltechTHESIS
Deposited By: Imported from ETD-db
Deposited On:11 Nov 2008
Last Modified:10 Dec 2014 19:47

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