Chen, Yan (2009) Integration of dye lasers and microfluidics for biochemical analysis. Dissertation (Ph.D.), California Institute of Technology. http://resolver.caltech.edu/CaltechETD:etd-07202008-164745
This dissertation describes the study of two important aspects of integration in microfluidics: optics and biochemistry. In optics integration, two types of miniaturized dye lasers, namely the solid-state polymer dye lasers and optofluidic dye lasers were demonstrated. Both of the dye lasers possess a resonant cavity with circular grating geometry, and they are suitable to serve as low-threshold, surface-emitting coherent light source in microfluidic networks. The mass production and large scale fabrication of such low-cost dye laser arrays can be realized by the well developed nanoimprint and soft lithography, making this technology attractive for various biochemical applications. In biochemistry integration, a microfluidic system was developed to fully utilize the complexity of microfluidic circuits to process single cells and extract gene expression information in a parallel manner. The work presented here explored both the optics and biochemistry integration in microfluidics, which are the key issues for further development of complete “lab-on-a-chip” systems.
|Item Type:||Thesis (Dissertation (Ph.D.))|
|Subject Keywords:||circular grating; dye laser; microfluidics; nanoimprint|
|Degree Grantor:||California Institute of Technology|
|Division:||Engineering and Applied Science|
|Thesis Availability:||Public (worldwide access)|
|Defense Date:||18 July 2008|
|Default Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Imported from ETD-db|
|Deposited On:||11 Nov 2008|
|Last Modified:||26 Dec 2012 03:16|
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