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Integration of dye lasers and microfluidics for biochemical analysis


Chen, Yan (2009) Integration of dye lasers and microfluidics for biochemical analysis. Dissertation (Ph.D.), California Institute of Technology.


This dissertation describes the study of two important aspects of integration in microfluidics: optics and biochemistry. In optics integration, two types of miniaturized dye lasers, namely the solid-state polymer dye lasers and optofluidic dye lasers were demonstrated. Both of the dye lasers possess a resonant cavity with circular grating geometry, and they are suitable to serve as low-threshold, surface-emitting coherent light source in microfluidic networks. The mass production and large scale fabrication of such low-cost dye laser arrays can be realized by the well developed nanoimprint and soft lithography, making this technology attractive for various biochemical applications. In biochemistry integration, a microfluidic system was developed to fully utilize the complexity of microfluidic circuits to process single cells and extract gene expression information in a parallel manner. The work presented here explored both the optics and biochemistry integration in microfluidics, which are the key issues for further development of complete “lab-on-a-chip” systems.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:circular grating; dye laser; microfluidics; nanoimprint
Degree Grantor:California Institute of Technology
Division:Engineering and Applied Science
Major Option:Bioengineering
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Scherer, Axel
Thesis Committee:
  • Scherer, Axel (chair)
  • Yang, Changhuei
  • Guo, Chin-Lin
  • Painter, Oskar J.
  • Tai, Yu-Chong
Defense Date:18 July 2008
Record Number:CaltechETD:etd-07202008-164745
Persistent URL:
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:5238
Deposited By: Imported from ETD-db
Deposited On:11 Nov 2008
Last Modified:10 Dec 2014 19:47

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