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Control systems theory applied to metabolic homeostatic systems and the derivation and identification of mathematical models

Citation

Charette, Wilfred P. (1969) Control systems theory applied to metabolic homeostatic systems and the derivation and identification of mathematical models. Dissertation (Ph.D.), California Institute of Technology. http://resolver.caltech.edu/CaltechETD:etd-10072002-135255

Abstract

The relations among organs and processes resulting in the hormonal control of human metabolism are interpreted mathematically for the derivation and analysis of models using control systems theory and systems engineering techniques. A dynamic nonlinear model for glucose homeostasis including four controlling hormones is derived from the current biological knowledge of the normal system and simulated for comparison with experimental data. Mathematical algorithms are developed and demonstrated for the identification of the parameters of the proposed model and a series of experiments is proposed to yield the minimal requisite data for the application of the method. Control systems analyses are undertaken on the proposed model to demonstrate a consistent methodology for investigations of complex metabolic control systems in the intact animal

Item Type:Thesis (Dissertation (Ph.D.))
Degree Grantor:California Institute of Technology
Division:Engineering and Applied Science
Major Option:Electrical Engineering
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Sridhar, Rangasami
Thesis Committee:
  • Unknown, Unknown
Defense Date:17 July 1968
Record Number:CaltechETD:etd-10072002-135255
Persistent URL:http://resolver.caltech.edu/CaltechETD:etd-10072002-135255
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:3953
Collection:CaltechTHESIS
Deposited By: Imported from ETD-db
Deposited On:07 Oct 2002
Last Modified:26 Dec 2012 03:04

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