Branchaud, Edward A. (2006) A control system for positioning recording electrodes to isolate neurons in extracellular recordings. Dissertation (Ph.D.), California Institute of Technology. http://resolver.caltech.edu/CaltechETD:etd-06042006-160620
This thesis presents an algorithm that autonomously positions recording electrodes inside cortical tissue so as to isolate and then maintain optimal extracellular signal recording quality without human intervention. The algorithm is used to improve the quality and efficiency of acute (daily insertion) recordings that are needed for basic research in neurophysiology. It also offers the potential to increase the longevity and quality of chronic (long-term implant) recordings by controlling an emerging class of chronic arrays in which the electrodes can be continually repositioned after implantation.
The challenges encountered in attempting to isolate neurons are studied. A solution is proposed in which a finite state machine oversees a number of signal processing steps, computes various metrics of the recording quality and issues commands to move the electrode close to neurons without causing them damage. A number of metrics of the quality of neuron isolation are compared.
The algorithm has been used to control a number of commercial microdrive systems, including a single-electrode FHC microdrive and multielectrode microdrives from Thomas Recording and NAN, as well as a novel miniature microdrive. The autonomous positioning software is used by several neuroscientists to perform basic neurophysiology research. Analysis of the system's performance in isolating neurons is included.
|Item Type:||Thesis (Dissertation (Ph.D.))|
|Subject Keywords:||electrode positioning; extracellular neural recording; neuron isolation|
|Degree Grantor:||California Institute of Technology|
|Division:||Engineering and Applied Science|
|Major Option:||Mechanical Engineering|
|Thesis Availability:||Public (worldwide access)|
|Defense Date:||24 May 2006|
|Author Email:||ebranchaud (AT) gmail.com|
|Default Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Imported from ETD-db|
|Deposited On:||05 Jun 2006|
|Last Modified:||26 Dec 2012 02:51|
- Final Version
See Usage Policy.
Repository Staff Only: item control page