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DNA-mediated charge transport in DNA repair

Citation

Boal, Amie Kathleen (2008) DNA-mediated charge transport in DNA repair. Dissertation (Ph.D.), California Institute of Technology. http://resolver.caltech.edu/CaltechETD:etd-06022008-092549

Abstract

The double-helical structure of deoxyribonucleic acid (DNA) imparts upon this important biological molecule both the ability to store genetic information within a cell and also the capacity to serve as medium for charge transport. DNA-mediated charge transport is now a very well-studied phenomenon but biological roles for these reactions have not been explored. It has been demonstrated that DNA-mediated charge transport can funnel oxidative DNA damage to sites of low oxidation potential in a number of biologically relevant environments ranging from reconstituted nucleosome core particles, to isolated nuclei and mitochondria from HeLa cells. DNA-mediated charge transport may also play a role in transcriptional activation or repression as modulated by redox-active transcription factors. Here we examine how DNA-mediated charge migration could also provide a pathway for protein-protein communication among DNA repair enzymes, a pathway that might serve as a scheme for rapid lesion detection inside the cell.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:BER glycosylase; DNA charge transport; DNA repair; EndoIII; iron-sulfur cluster; MutY
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Awards:The Herbert Newby McCoy Award, 2008
Thesis Availability:Mixed availability, specified at file level
Research Advisor(s):
  • Barton, Jacqueline K.
Thesis Committee:
  • Parker, Carl Stevens (chair)
  • Gray, Harry B.
  • Barton, Jacqueline K.
  • Lewis, Nathan Saul
Defense Date:1 May 2008
Record Number:CaltechETD:etd-06022008-092549
Persistent URL:http://resolver.caltech.edu/CaltechETD:etd-06022008-092549
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:2408
Collection:CaltechTHESIS
Deposited By: Imported from ETD-db
Deposited On:05 Jun 2008
Last Modified:26 Dec 2012 02:51

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