Browse by Advisor

2024

Gao, Shilong (2024) Engineering Heme Proteins for C(sp³)–H Primary Amination. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/gsmr-b827. https://resolver.caltech.edu/CaltechTHESIS:08242023-170135027

Johnston, Kadina Elizabeth (2024) Acquiring Enzyme Sequence-Fitness Data at Scale Toward Predictive Methods for Enzyme Engineering. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/xjz4-k217. https://resolver.caltech.edu/CaltechTHESIS:09212023-182422125

Wackelin, Daniel Joseph (2024) New to Nature C–C Bond Forming Cyclases: Pushing the Boundaries of Ring Forming Reactions. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/26ag-8c56. https://resolver.caltech.edu/CaltechTHESIS:09022023-064950039

2023

Almhjell, Patrick James (2023) Noncanonical Amino Acid Synthesis by Evolved Tryptophan Synthases. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/rcvq-dg51. https://resolver.caltech.edu/CaltechTHESIS:10172022-224813021

Sarai, Nicholas Singh (2023) Engineering Cytochrome P450BM3 for Oxidation and Silicon–Carbon Bond Cleavage of Volatile Methylsiloxanes. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/gn1j-fz77. https://resolver.caltech.edu/CaltechTHESIS:05152023-034200704

2022

Goldberg, Nathaniel Wood (2022) Non-Native Chemistry of Metalloenzymes. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/6sec-zx89. https://resolver.caltech.edu/CaltechTHESIS:02232022-224045858

Watkins-Dulaney, Ella Jenná (2022) Engineering the Tryptophan Synthase β-Subunit for Synthesis of Noncanonical Amino Acids. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/yekm-y267. https://resolver.caltech.edu/CaltechTHESIS:07062021-155047044

Wittmann, Bruce James (2022) Strategies and Tools for Machine Learning-Assisted Protein Engineering. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/azzt-0q97. https://resolver.caltech.edu/CaltechTHESIS:05262022-234214451

Zhang, Juner (2022) New-to-Nature Selective C-H Alkylation Using Engineered Carbene Transferases. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/4kv8-f830. https://resolver.caltech.edu/CaltechTHESIS:04252022-204451583

2021

Knight, Anders Matthew (2021) Expanding the Scope of Metalloprotein Families and Substrate Classes in New-to-Nature Reactions. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/7qh5-5130. https://resolver.caltech.edu/CaltechTHESIS:06212020-111155395

Wu, Zachary (2021) Data-Driven Protein Engineering. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/nx3c-qb44. https://resolver.caltech.edu/CaltechTHESIS:01042021-220032574

Zhou, Andrew Z. (2021) Biocatalytic Lactone Carbene C–H, B–H, and N–H Insertion Reactions Enabled by Directed Evolution. Senior thesis (Major), California Institute of Technology. doi:10.7907/zqcp-jt95. https://resolver.caltech.edu/CaltechThesis:06232021-201833496

2020

Chen, Kai (2020) Expanding the Catalytic Repertoire of Hemeproteins as Carbene Transferases to Access Diverse Molecular Structures. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/9b3c-nr61. https://resolver.caltech.edu/CaltechTHESIS:05192020-111207482

2019

Lewis, Russell DeRieux (2019) Evolution and Characterization of Carbene Transferases for Cyclopropanation and Carbon–Silicon Bond Formation. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/RMEX-Q134. https://resolver.caltech.edu/CaltechTHESIS:06052019-172451535

Yang, Kevin Kaichuang (2019) Probabilistic Protein Engineering. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/ZR4M-K630. https://resolver.caltech.edu/CaltechTHESIS:12222018-173706714

Zhang, Ruijie (2019) Engineering Heme Proteins for Olefin and Carbon−Hydrogen Bond Functionalization Reactions. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/2076-CX23. https://resolver.caltech.edu/CaltechTHESIS:03102019-234035587

2018

Bedbrook, Claire Nicole (2018) Engineering Novel Rhodopsins for Neuroscience. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/7RA0-BC29. https://resolver.caltech.edu/CaltechTHESIS:05302018-095950094

2016

Cahn, Jackson Kenai Blender (2016) Engineering, Predicting, and Understanding Nicotinamide Cofactor Specificity. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/Z9QV3JJ8. https://resolver.caltech.edu/CaltechTHESIS:01212016-225223309

2015

Farwell, Christopher C. (2015) Engineering and Characterization of Cytochrome P450 Enzymes for Nitrogen-Atom Transfer Reactions. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/Z9765C71. https://resolver.caltech.edu/CaltechTHESIS:01302015-155404718

2014

Trudeau, Devin Lee (2014) Engineering Enzyme Systems by Recombination. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/F8T8-3S80. https://resolver.caltech.edu/CaltechTHESIS:01202014-144143175

2013

Coelho, Pedro de Souza Leão (2013) Olefin Cyclopropanation and Carbon-Hydrogen Amination via Carbene and Nitrene Transfers Catalyzed by Engineered Cytochrome P450 Enzymes. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/HSPH-AF89. https://resolver.caltech.edu/CaltechTHESIS:04072013-230318757

Kalbarczyk, Karolina Zbigniew (2013) Directed Evolution of Terpene Synthases for Non-Natural Substrates. Senior thesis (Major), California Institute of Technology. doi:10.7907/N4T5-FP16. https://resolver.caltech.edu/CaltechTHESIS:05302013-204117395

Smith, Matthew Alexander (2013) Non-Contiguous Protein Recombination. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/4B8E-ZH08. https://resolver.caltech.edu/CaltechTHESIS:04102013-164733450

Wu, Indira (2013) Engineering Thermostable Fungal Cellobiohydrolases. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/V80F-X625. https://resolver.caltech.edu/CaltechTHESIS:05022013-164749371

2012

Komor, Russell Scott (2012) Recombinatorial and Predictive Methods to Increase Cellulase Thermostability and Structural Analysis of a Thermostable P450. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/A1ZX-3W42. https://resolver.caltech.edu/CaltechTHESIS:12212011-144253704

Romero, Philip Anthony (2012) Statistical Models of the Protein Fitness Landscape: Applications to Protein Evolution and Engineering. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/7W9R-Y338. https://resolver.caltech.edu/CaltechTHESIS:03172012-160452929

2011

Chen, Mike Ming Yu (2011) Directed Evolution of Cytochrome P450 for Small Alkane Hydroxylation. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/T154-RW89. https://resolver.caltech.edu/CaltechTHESIS:05042011-114651954

2010

Carbone, Martina Nini (2010) Characterization of the Functional Diversity and Evolvability of Chimeric Enzymes Assembled by Structure-Guided SCHEMA Recombination. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/QE98-1921. https://resolver.caltech.edu/CaltechTHESIS:05272010-170914354

2009

Brenner, Sarah Katherine (2009) Engineering Synthetic Biofilm-Forming Microbial Consortia. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/PMZ3-4Z96. https://resolver.caltech.edu/CaltechETD:etd-04212009-104756

2008

Otey, Christopher Richard (2008) Structural and Functional Exploration of an Artificial Family of Cytochromes P450. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/MZQM-N011. https://resolver.caltech.edu/CaltechETD:etd-06112008-094638

2007

Bloom, Jesse D. (2007) Hidden Dimensions in Protein Evolution: Stability, Mutational Robustness, and Evolvability. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/3MNT-7W93. https://resolver.caltech.edu/CaltechETD:etd-05232007-094635

2006

Collins, Cynthia Hollie (2006) Directed Evolution of the Transcriptional Activator LuxR. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/61qd-8j79. https://resolver.caltech.edu/CaltechETD:etd-12272005-160649

Drummond, David Allan (2006) Misfolding Dominates Protein Evolution. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/DH8E-2N10. https://resolver.caltech.edu/CaltechETD:etd-06022006-154329

Meyer, Michelle Margaret (2006) Exploring Protein Sequence Space Using Computationally Directed Recombination. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/YJPE-CD11. https://resolver.caltech.edu/CaltechETD:etd-05262006-112358

Tobias, Alexander Vincent (2006) Directed Evolution of Biosynthetic Pathways to Carotenoids with Unnatural Carbon Backbones. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/WF0Q-2J98. https://resolver.caltech.edu/CaltechETD:etd-08232005-174620

2005

Endelman, Jeffrey B. (2005) Design and Analysis of Combinatorial Protein Libraries Created by Site-Directed Recombination. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/GF35-Q269. https://resolver.caltech.edu/CaltechETD:etd-06022005-192548

Meinhold, Peter (2005) Engineering Cytochrome P450 BM-3 for Selective Hydroxylation of Alkanes. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/aats-ca30. https://resolver.caltech.edu/CaltechETD:etd-06032005-113204

Udit, Andrew K. (2005) P450 BM3 Electrochemistry and Electrocatalysis. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/wr4v-d345. https://resolver.caltech.edu/CaltechETD:etd-05112005-100825

2004

Cirino, Patrick Carmen (2004) Laboratory Evolution of Cytochrome P450 Peroxygenase Activity. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/KWGR-DF47. https://resolver.caltech.edu/CaltechETD:etd-06062003-164310

2003

Joern, John Michael (2003) Engineering Dioxygenases by Laboratory Evolution: A Comparison of Evolutionary Search Strategies. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/61KV-P379. https://resolver.caltech.edu/CaltechETD:etd-02042003-160317

Sun, Lianhong (2003) Engineering Galactose Oxidase to Increase Expression Level in E. coli, Enhance Thermostability and Introduce Novel Activities. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/PZ0M-T047. https://resolver.caltech.edu/CaltechETD:etd-10032002-101924

Thorsen, Todd Addison (2003) Microfluidic Technologies for High-Throughput Screening Applications. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/QGWY-VX32. https://resolver.caltech.edu/CaltechETD:etd-12012002-092026

Voigt, Christopher Ashby (2003) Computationally Optimizing the Directed Evolution of Proteins. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/E4GF-EQ41. https://resolver.caltech.edu/CaltechETD:etd-08192002-161141

2002

Fu, Anne Yen-Chen (2002) Microfabricated Fluorescence-Activated Cell Sorters (µFACS) for Screening Bacterial Cells. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/6HKD-RQ61. https://resolver.caltech.edu/CaltechETD:etd-05132002-124824

1998

Zhao, Huimin (1998) Enzyme Design by Directed Evolution. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/3bcb-4g98. https://resolver.caltech.edu/CaltechETD:etd-05042006-105832

1996

Shnek, Deborah Rebecca (1996) Targeting of proteins and protein analogs to metal-chelating lipid vesicles. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/ctnn-4057. https://resolver.caltech.edu/CaltechETD:etd-01032008-092017

1995

Johnson, Robert David (1995) Multivalent protein binding to metal-complexing materials : applications to synthetic receptors and affinity chromatography. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/6kdk-t643. https://resolver.caltech.edu/CaltechETD:etd-10122007-091509

1991

Claeys, Ivan Lode Andre Maria (1991) Hydrodynamic Transport Properties of Suspensions of Non-Brownian Prolate Spheroids. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/DYJ3-4223. https://resolver.caltech.edu/CaltechETD:etd-01282005-165455