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Simulation of Shock-Induced Bubble Collapse with Application to Vascular Injury in Shockwave Lithotripsy


Coralic, Vedran (2015) Simulation of Shock-Induced Bubble Collapse with Application to Vascular Injury in Shockwave Lithotripsy. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/Z91N7Z26.


Shockwave lithotripsy is a noninvasive medical procedure wherein shockwaves are repeatedly focused at the location of kidney stones in order to pulverize them. Stone comminution is thought to be the product of two mechanisms: the propagation of stress waves within the stone and cavitation erosion. However, the latter mechanism has also been implicated in vascular injury. In the present work, shock-induced bubble collapse is studied in order to understand the role that it might play in inducing vascular injury. A high-order accurate, shock- and interface-capturing numerical scheme is developed to simulate the three-dimensional collapse of the bubble in both the free-field and inside a vessel phantom. The primary contributions of the numerical study are the characterization of the shock-bubble and shock-bubble-vessel interactions across a large parameter space that includes clinical shockwave lithotripsy pressure amplitudes, problem geometry and tissue viscoelasticity, and the subsequent correlation of these interactions to vascular injury. Specifically, measurements of the vessel wall pressures and displacements, as well as the finite strains in the fluid surrounding the bubble, are utilized with available experiments in tissue to evaluate damage potential. Estimates are made of the smallest injurious bubbles in the microvasculature during both the collapse and jetting phases of the bubble's life cycle. The present results suggest that bubbles larger than 1 μm in diameter could rupture blood vessels under clinical SWL conditions.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:Bubble dynamics; Interface-capturing; Shock-capturing; Shock-induced collapse; Shockwave lithotripsy; Vascular injury
Degree Grantor:California Institute of Technology
Division:Engineering and Applied Science
Major Option:Mechanical Engineering
Awards:Richard Bruce Chapman Memorial Award, 2015
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Colonius, Tim
Thesis Committee:
  • Shepherd, Joseph E. (chair)
  • Blanquart, Guillaume
  • Brady, John F.
  • Colonius, Tim
Defense Date:18 September 2014
Funding AgencyGrant Number
NSF Graduate Research FellowshipUNSPECIFIED
Record Number:CaltechTHESIS:01222015-234921548
Persistent URL:
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:8758
Deposited By: Vedran Coralic
Deposited On:04 Feb 2015 22:39
Last Modified:26 Oct 2023 19:40

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