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Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection


Khosravi, Arya (2014) Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/XM07-4X53.


The commensal microbiota impacts specific immune cell populations and their functions at peripheral sites, such as gut mucosal tissues. However, it remains unknown whether gut microbiota control immunity through regulation of hematopoiesis at primary immune sites. We reveal that germ-free mice display reduced proportions and differentiation potential of specific myeloid cell progenitors of both yolk sac and bone marrow origin. Homeostatic innate immune defects may lead to impaired early responses to pathogens. Indeed, following systemic infection with Listeria monocytogenes, germ-free and oral antibiotic-treated mice display increased pathogen burden and acute death. Recolonization of germ-free mice with a complex microbiota restores defects in myelopoiesis and resistance to Listeria. These findings reveal that gut bacteria direct innate immune cell development via promoting hematopoiesis, contributing to our appreciation of the deep evolutionary connection between mammals and their microbiota.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:microbiota ; hematopoiesis ; infection ; macrophage
Degree Grantor:California Institute of Technology
Division:Biology and Biological Engineering
Major Option:Biology
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Mazmanian, Sarkis K.
Thesis Committee:
  • Rothenberg, Ellen V. (chair)
  • Baltimore, David L.
  • Patterson, Paul H.
  • Mazmanian, Sarkis K.
Defense Date:24 March 2014
Record Number:CaltechTHESIS:04242014-100521885
Persistent URL:
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:8201
Deposited By: Arya Khosravi
Deposited On:07 May 2014 17:08
Last Modified:04 Oct 2019 00:04

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