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State-Dependent Modulation of Neuronal Circuits in C. elegans Sleep

Citation

Cho, Julie YoungHee (2013) State-Dependent Modulation of Neuronal Circuits in C. elegans Sleep. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/Z9028PF1. http://resolver.caltech.edu/CaltechTHESIS:05312013-162338827

Abstract

C. elegans is a compact system of 302 neurons with identifiable and mapped connections that makes it ideal for systems analysis. This work is a demonstration of what I have been able to learn about the nature of state-specific modulation and reversibility during a state called lethargus, a sleep-like state in the worm. I begin with description about the nervous system of the worm, the nature of sleep in the worm, the questions about behavior and its apparent circuit properties, the tools available and used to manipulate the nervous system, and what I have been able to learn from these studies. I end with clues that the physiology helps to teach us about the dynamics of state specific modulation, what makes sleep so different from other states, and how we can use these measurements to understand which modulators, neurotransmitters, and channels can be used to create different dynamics in a simple model system.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:neuronal circuits, sleep, optogenetics, sensory motor circuit
Degree Grantor:California Institute of Technology
Division:Biology
Major Option:Biology
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Sternberg, Paul W.
Thesis Committee:
  • Anderson, David J. (chair)
  • Prober, David A.
  • Konishi, Masakazu
  • Siapas, Athanassios G.
  • Sternberg, Paul W.
Defense Date:2 May 2013
Record Number:CaltechTHESIS:05312013-162338827
Persistent URL:http://resolver.caltech.edu/CaltechTHESIS:05312013-162338827
DOI:10.7907/Z9028PF1
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7805
Collection:CaltechTHESIS
Deposited By: Julie Cho
Deposited On:06 Jun 2013 22:26
Last Modified:26 Jan 2019 00:16

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