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Studies on the On-Line Identification and Optimal Control of Bioreactors


San, Ka-Yiu (1984) Studies on the On-Line Identification and Optimal Control of Bioreactors. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/b5p1-5c02.


An integrated approach is presented for the on-line estimation of the state of a biochemical reactor from presently attainable real-time measurements. Elemental and macroscopic balances are used for the determination of the total rate of growth and state-of-the-art estimation techniques are subsequently employed for the elimination of process and measurement noise and the estimation of the state variables and unknown culture parameters. The proposed approach is very flexible in that as new sensors become available they can be easily incorporated within the present framework to estimate new variables or improve the accuracy of the old ones. The method does not require any model for the growth kinetics and is very sucessful in accurately estimating the above variables in the presence of intense noise and under both steady state and transient conditions. Computer simulation as well as experimental results obtained from this study clearly demonstrate the superb performance of such estimation methodology. State estimates obtained by the proposed method can be used for the development of adaptive optimal control schemes as well as for basic studies of the characteristic properties of microbial cultures.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:Chemical Engineering
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemical Engineering
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Stephanopoulos, Gregory N.
Thesis Committee:
  • Bailey, James E. (chair)
  • Gavalas, George R.
  • Hoffmann, Michael R.
  • Stephanopoulos, Gregory N.
Defense Date:4 January 1984
Funding AgencyGrant Number
Record Number:CaltechETD:etd-01082007-153733
Persistent URL:
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66
Deposited By: Imported from ETD-db
Deposited On:09 Jan 2007
Last Modified:16 Apr 2021 22:23

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