The Structure and Biogenesis of Nidulin

Citation

Beach, William Frederick (1962) The Structure and Biogenesis of Nidulin. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/3RME-0Q76. https://resolver.caltech.edu/CaltechTHESIS:07282011-084657541

Abstract

The structure of nidulin, the major metabolic product of Aspergillus nidulans, is demonstrated beyond reasonable doubt to be that which was set forth recently by other workers. In support of the structure, a xanthene was isolated and characterized. It was also discovered that nidulin suffered a remarkably facile dechlorination in the presence of hydrobromic acid and red phosphorous. Preliminary tracer experiments with labelled acetate were performed, and the expected pattern of incorporation was observed. Isoleucine was likewise shown to be incorporated into nidulin. A possible biogenesis for nidulin is discussed which points the way for future research.

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