Citation
Brueckner, David Armstrong (1966) Studies in enzyme crystallography. Master's thesis, California Institute of Technology. doi:10.7907/W06N-8494. https://resolver.caltech.edu/CaltechTHESIS:05062010-111323235
Abstract
This thesis presents X-ray crystallographic research on chymotrypsin and lysozyme. Seven crystal types of chymotrypsin were identified -- five for the first time. The seven crystal types appear to be different packings of two conformations of the same molecule. One crystal type of lysozyme was studied. From Patterson projections of crystals diffused with PtI_6^= ions, the x, y, and z coordinates for these ions were determined. After one least squares refinement of these coordinates, the agreement factor between calculated and observed contributions of the PtI_6^= ions was 0.34 for 108 hkO and hOl reflections. Using these coordinates, an hkO and an hOl Fourier projection were prepared. X and y coordinates for the heavy atoms in lysozyme crystals diffused with UO_2^(++) ions, WO_4^= ions, HgI_4^= ions, HgCl_2, ThCl_4, and p-ClHgфSO_3H were determined from Patterson and Fourier projections.
Item Type: | Thesis (Master's thesis) |
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Subject Keywords: | Chemistry |
Degree Grantor: | California Institute of Technology |
Division: | Chemistry and Chemical Engineering |
Major Option: | Chemistry |
Thesis Availability: | Public (worldwide access) |
Research Advisor(s): |
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Thesis Committee: |
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Defense Date: | 1 January 1966 |
Record Number: | CaltechTHESIS:05062010-111323235 |
Persistent URL: | https://resolver.caltech.edu/CaltechTHESIS:05062010-111323235 |
DOI: | 10.7907/W06N-8494 |
Default Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. |
ID Code: | 5776 |
Collection: | CaltechTHESIS |
Deposited By: | Tony Diaz |
Deposited On: | 09 Aug 2010 22:35 |
Last Modified: | 21 Dec 2019 03:06 |
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