A Caltech Library Service

The Synthesis of O-Methyl-N-Acetyl-L-Tyrosine


Brady, William Thomas (1957) The Synthesis of O-Methyl-N-Acetyl-L-Tyrosine. Master's thesis, California Institute of Technology. doi:10.7907/2XEN-8E12.


An efficient method of preparing N-acetyl-L-tyrosine methyl ester is described. This compound has been converted to the optically pure O-methyl derivative by reaction with diazomethane. The saponification of N-acetyl-L-tyrosine methyl ester is a more convenient rout to N-acetyl-L-tyrosine than the direct acetylation of L-tyrosine. N-acetyl-L-tyrosine can be converted to optically pure O-methylN-acetyl-L-tyrosine via the Williamson synthesis. The preparation of several other derivatives of L- tyrosine is also described.

Item Type:Thesis (Master's thesis)
Subject Keywords:(Chemistry)
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Niemann, Carl G.
Thesis Committee:
  • Unknown, Unknown
Defense Date:1 January 1957
Record Number:CaltechTHESIS:04292010-095951946
Persistent URL:
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:5752
Deposited By: Tony Diaz
Deposited On:07 Jul 2010 15:21
Last Modified:15 Aug 2023 20:33

Thesis Files

PDF - Final Version
See Usage Policy.


Repository Staff Only: item control page