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The preparation and properties of large lecithin bilayer vesicles


Hurley, John N. (1974) The preparation and properties of large lecithin bilayer vesicles. Master's thesis, California Institute of Technology. doi:10.7907/M7HY-MS72.


Sonicated lecithin vesicles of an "average" diameter of 1200 Å were prepared. PMR studies show a higher phase transition temperature than that found for small (300 - 500 Å) vesicles. Osmotic pressure collapses the vesicle but does not change the PMR linewidth. This differs from the effect found in small vesicles. Upon addition of a cyclic polyether (cyclohexyl-15-crown-5) to a solution of large vesicles, the water diffusion rate is found to increase by a factor of 5 to 10. The internal water volume also increases significantly, suggesting that the crown compound is incorporated into the bilayer.

Item Type:Thesis (Master's thesis)
Subject Keywords:Chemistry
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Chan, Sunney I.
Thesis Committee:
  • Unknown, Unknown
Defense Date:September 1973
Record Number:CaltechTHESIS:11132009-091109533
Persistent URL:
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:5373
Deposited By: Tony Diaz
Deposited On:17 Nov 2009 21:59
Last Modified:21 Dec 2019 03:03

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