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Genetic and biochemical studies of the cystine-methionine series of mutants in Neurospora crassa


Fischer, Glenn Albert (1954) Genetic and biochemical studies of the cystine-methionine series of mutants in Neurospora crassa. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/FP61-BW75.


NOTE: Text or symbols not renderale in plain ASCII are indicated by [...]. Abstract is included in .pdf document.

1. The following enzyme activities were studied in extracts of wild type and mutant Neurospora: [...]. Activity 2 was shown to be absent in a homocysteineless mutant and activity 3 was shown to be absent in a cystathionineless mutant. It was found that a suppressor, obtained by Giles, which causes these mutants to grow on minimal, returns enzyme activity to the mutants. Each activity is shown to be catalyzed by a different enzyme.

2. Evidence is presented which indicates that a Neurospora cystathionineless mutant can synthesize cystathionine from methionine without the intervention of cysteine.

3. Mutants which are blocked between thiosulfate and cysteine are shown to grow on elemental sulfur and H[subscript 2]S.

Item Type:Thesis (Dissertation (Ph.D.))
Degree Grantor:California Institute of Technology
Major Option:Biology
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Horowitz, Norman Harold
Thesis Committee:
  • Unknown, Unknown
Defense Date:1 January 1954
Record Number:CaltechETD:etd-12102003-111246
Persistent URL:
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:4924
Deposited By: Imported from ETD-db
Deposited On:12 Dec 2003
Last Modified:21 Dec 2019 02:09

Thesis Files

PDF (Fischer_ga_1954.pdf) - Final Version
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