Immunoglobulins: Structure, Genetics and Evolution

Citation

Hood, Leroy Edward (1968) Immunoglobulins: Structure, Genetics and Evolution. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/3ZM8-A807. https://resolver.caltech.edu/CaltechETD:etd-09162004-110314

Abstract

The immune system is capable of generating an immense number of different antibody molecules. The nature of the genetic machinery responsible for this diversity has been studied by selective amino acid sequence analysis of homogeneous immunoglobulin light chains (derived from myeloma tumors). The evolution of the immune system has also been examined through chemical studies of normal pooled light chains derived from various mammalian and avian species. These studies place constraints on proposed genetic mechanisms for antibody diversity. The theories, the structural constraints, and the evolutionary implications of these observations are discussed.

Item Type:

Thesis (Dissertation (Ph.D.))

Subject Keywords:

(Biochemistry)

Degree Grantor:

California Institute of Technology

Division:

Biology

Major Option:

Biochemistry

Thesis Availability:

Public (worldwide access)

Research Advisor(s):

Dreyer, William J.

Thesis Committee:

Unknown, Unknown

Defense Date:

29 November 1967

Additional Information:

Thesis title varies in the 1968 Commencement Program: Antibodies: Structure, Genetics and Evolution.

Record Number:

CaltechETD:etd-09162004-110314

Persistent URL:

https://resolver.caltech.edu/CaltechETD:etd-09162004-110314

DOI:

10.7907/3ZM8-A807

ORCID:

Author	ORCID
Hood, Leroy Edward	0000-0001-7158-3678

Default Usage Policy:

No commercial reproduction, distribution, display or performance rights in this work are provided.

ID Code:

3561

Collection:

CaltechTHESIS

Deposited By:

Imported from ETD-db

Deposited On:

17 Sep 2004

Last Modified:

02 Apr 2024 18:25

Thesis Files

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