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Immunoglobulins: Structure, Genetics and Evolution


Hood, Leroy Edward (1968) Immunoglobulins: Structure, Genetics and Evolution. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/3ZM8-A807.


The immune system is capable of generating an immense number of different antibody molecules. The nature of the genetic machinery responsible for this diversity has been studied by selective amino acid sequence analysis of homogeneous immunoglobulin light chains (derived from myeloma tumors). The evolution of the immune system has also been examined through chemical studies of normal pooled light chains derived from various mammalian and avian species. These studies place constraints on proposed genetic mechanisms for antibody diversity. The theories, the structural constraints, and the evolutionary implications of these observations are discussed.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:Biochemistry
Degree Grantor:California Institute of Technology
Major Option:Biochemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Dreyer, William J.
Thesis Committee:
  • Unknown, Unknown
Defense Date:29 November 1967
Additional Information:Thesis title varies in 1968 Commencement Program: Antibodies : Structure, Genetics and Evolution.
Record Number:CaltechETD:etd-09162004-110314
Persistent URL:
Hood, Leroy Edward0000-0001-7158-3678
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:3561
Deposited By: Imported from ETD-db
Deposited On:17 Sep 2004
Last Modified:21 Dec 2019 04:57

Thesis Files

PDF (Hood_le_1968.pdf) - Final Version
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