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Voltage gateable ionic pores induced by alamethicin in black lipid membranes


Eisenberg-Grunberg, Moises (1973) Voltage gateable ionic pores induced by alamethicin in black lipid membranes. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/2YFT-Q653.


The strongly surface-active polypeptide antibiotic alamethicin (m.w. ~ 1700) interacts with artificial black lipid membranes to form voltage gateable ionic channels with five discrete conductance states. The channels fluctuate between these states with transition rates which depend little on the applied voltage. Within any conductance state, the behavior is approximately ohmic and similar to bulk solutions. When added on one side only, alamethicin confers upon a phosphatidyl-ethanolamine-decane black film a pronounced asymmetry. The alamethicin channels are only slightly ion selective, their rate of formation is strongly dependent on the alamethicin concentration, on the voltage across the membrane and on the ionic strengths.

Item Type:Thesis (Dissertation (Ph.D.))
Degree Grantor:California Institute of Technology
Division:Engineering and Applied Science
Major Option:Biology
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Delbruck, Max (advisor)
  • Mead, Carver (advisor)
Thesis Committee:
  • Unknown, Unknown
Defense Date:12 September 1972
Record Number:CaltechETD:etd-08092006-125321
Persistent URL:
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:3073
Deposited By: Imported from ETD-db
Deposited On:09 Aug 2006
Last Modified:21 Dec 2019 03:57

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PDF (Eisenberg-Grunberg_m_1973.pdf) - Final Version
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