Hydrophilic Polymers in Gels and Solutions: Surface Properties and Structure

Citation

Mackel, Michael John (2008) Hydrophilic Polymers in Gels and Solutions: Surface Properties and Structure. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/5ZVF-6156. https://resolver.caltech.edu/CaltechETD:etd-05192008-134942

Abstract

Changes in the wetting properties of thin films of polyethyleneglycol (PEG) end-capped with fluoroalkyl groups are measured when the films are equilibrated at various relative humidity (RH). At high RH, the advancing contact angle on the surfaces is 20º higher than the advancing contact angle measured at low RH. The surprising transition to non-wetting character at high RH is attributed to fluoroalkyl groups ordering at the air-hydrogel interface when they are liberated by dissolution of PEG crystallites above 85% RH.

Next, the structure and tribology of a semi-interpenetrating hydrogel of agarose and an anionic polysaccharide (either hyaluronic acid or dextran sulfate) were studied. The porous structure of agarose allows incorporation of up to 2% dextran sulfate without weakening the gel’s mechanical properties. Addition of the polyelectrolyte endows the gels with shape memory upon drying and reswelling; the gel can be dehydrated and rapidly swollen back to its original dimensions. The addition of both dextran sulfate and hyaluronic acid (HA) increases the lubricity of agarose when tested against hydrophilic clean glass or hydrophobic fluorinated glass. Migration of the polyelectrolytes out of the gel is believed to make the gels self-lubricating.

Finally, hydrophilic polymers were functionalized with photoresponsive hyrophobes in an attempt to control polymer self-assembly with light. Micelles of PEG end-capped with azobenzene molecules showed no change in size when the solutions were irradiated with UV light. PEG block copolymers were also functionalized with azobenzene and used to modify gold surfaces, but photoresponsive contact angles could not be measured. Finally, acrylamides copolymerized with the vinyl derivatives of malachite green were also studied, but the copolymers proved unsuitable for use at moderate pH.

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