I. The Apparent Acid Dissociation Constants of Phenylalanine and Some of its Nuclearly Substituted Derivatives. II. The Isolation of Sphingosine from Bovine Spinal Cord. III. The Ultraviolet Absorption of Some O-Benzoyl Compounds

Citation

Nevenzel, Judd Cuthbert (1949) I. The Apparent Acid Dissociation Constants of Phenylalanine and Some of its Nuclearly Substituted Derivatives. II. The Isolation of Sphingosine from Bovine Spinal Cord. III. The Ultraviolet Absorption of Some O-Benzoyl Compounds. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/gshw-sd89. https://resolver.caltech.edu/CaltechTHESIS:10312023-210235284

Abstract

I. Apparent dissociation constants for the following compounds were determined by electrometric titration or ultraviolet spectroscopy: phenylalanine, ortho-, meta-, and parachloro-phenylalanines, para-sulfamido-phenylalanine, benzene sulfonamide, toluene sulfonamide, and methane sulfonamide.

II. The basic hydrolysis of sphingolipids to obtain sphingosine and psychosine was investigated, using both liquid ammonia and anhydrous hydrazine. Dilituric acid was found to be an excellent reagent for the precipitation of the sphingosine bases. The presence of dihydrosphingosine in bovine spinal cord was confirmed by isolation of the tribenzoyl derivative. The ultraviolet light extinction curve of this derivative was determined in ethanol.

III. The ultraviolet light extinction curves of methyl benzoate, "n-Octadecyl" benzoate, d, 1-di benzoyl n-octadecandiol-1,2, and benzoic anhydride were determined in hexane and those of the first and third compounds in ethanol.

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