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Nickel-Catalyzed Electroreductive Cross-Coupling Reactions of Anhydrides and Alkyl Halides


Chang, Daniel Kwon (2022) Nickel-Catalyzed Electroreductive Cross-Coupling Reactions of Anhydrides and Alkyl Halides. Master's thesis, California Institute of Technology. doi:10.7907/w0pr-fs28.


The formation of new carbon–carbon bonds is one of the most important transformations in organic chemistry due to its ability to build the backbone of organic molecules. Nickel-catalyzed reductive cross-coupling reactions have recently emerged as an efficient and powerful strategy for the creation of new carbon–carbon bonds. Furthermore, electrochemistry can be harnessed to overcome some of the challenges encountered in many of the reductive cross-coupling reactions in the literature. Herein, we discuss the development of a new electroreductive nickel-catalyzed cross-coupling of anhydrides with unactivated alkyl bromides in collaboration with Amgen to produce large amounts of substituted cyclobutane products.

Item Type:Thesis (Master's thesis)
Subject Keywords:Nickel, cross-coupling, electrochemistry
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Thesis Availability:Not set
Research Advisor(s):
  • Reisman, Sarah E.
Thesis Committee:
  • None, None
Defense Date:2022
Funding AgencyGrant Number
NSF Graduate Research FellowshipDGE‐1745301
Amgen Chem-Bio-Engineering AwardS.E.R
Record Number:CaltechTHESIS:05122022-031448609
Persistent URL:
Chang, Daniel Kwon0000-0003-4314-5886
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:14577
Deposited By: Daniel Chang
Deposited On:16 May 2022 18:04
Last Modified:13 Jul 2022 22:17

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