Citation
Holman, Elizabeth Anne (2022) Developing Technologies for Real-Time Whole-Organism Imaging via FTIR Spectromicroscopy. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/es4r-kq84. https://resolver.caltech.edu/CaltechTHESIS:08312021-211824138
Abstract
FTIR spectromicroscopy heavily resides in the domain of cell-based and tissue-based studies when focusing on its direct application to biological systems. The goal of the reported graduate research is to extend FTIR spectromicroscopy to multicellular whole-organism imaging, ideally for non-invasive, non-destructive, and label-free spatiochemical imaging of biological model Caenorhabditis elegans (C. elegans). With modern optics, detector, and light source technologies implemented at synchrotron facilities, this thesis focuses on exploring the feasibility of multicellular whole-organism imaging while identifying challenges and presenting working solutions for them.
| Item Type: | Thesis (Dissertation (Ph.D.)) | |||||||||
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| Subject Keywords: | FTIR, spectromicroscopy, infrared, chemical imaging, synchrotron, autonomous experimentation, peptoid, whole-organism | |||||||||
| Degree Grantor: | California Institute of Technology | |||||||||
| Division: | Chemistry and Chemical Engineering | |||||||||
| Major Option: | Chemistry | |||||||||
| Thesis Availability: | Restricted to Caltech community only | |||||||||
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| Defense Date: | 6 July 2021 | |||||||||
| Non-Caltech Author Email: | holman.ea (AT) protonmail.com | |||||||||
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| Record Number: | CaltechTHESIS:08312021-211824138 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechTHESIS:08312021-211824138 | |||||||||
| DOI: | 10.7907/es4r-kq84 | |||||||||
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| Default Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 14350 | |||||||||
| Collection: | CaltechTHESIS | |||||||||
| Deposited By: | Elizabeth Holman | |||||||||
| Deposited On: | 07 Sep 2021 19:15 | |||||||||
| Last Modified: | 06 Jan 2023 18:48 |
Thesis Files
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PDF
- Final Version
Restricted to Caltech community only until 6 July 2023. See Usage Policy. 3MB |
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PDF (Partial thesis. Sections temporarily restricted.)
- Final Version
See Usage Policy. 1MB |
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