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Host-Microbe Interactions Impacting and Mediated by Nervous Systems


Yoo, Bryan B. (2020) Host-Microbe Interactions Impacting and Mediated by Nervous Systems. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/1zv5-ve82.


Animals and microbes coevolved, and thus it is not surprising that the trillions of microorganisms that harmoniously inhabit the mammalian gastrointestinal tract (GIT), collectively termed the gut microbiome, continue to be implicated in healthy and disease states. However, less is known about the mechanisms by which these states are maintained, and how deviations from homeostasis (i.e., dysbiosis) occurr. This thesis explores the relationship between host-microbe interactions and the central and peripheral nervous systems. Specifically, the first chapter of this thesis explores how the microbiome differs is patients with multiple sclerosis and how these differences alter diseases outcomes in a mouse model of the disease. Next, we introduce the enteric nervous system (ENS), the intrinsic nervous system of the GI tract which is supposed as a major conduit of the bidirectional communication between the gut and the brain. Lastly, by adopting biotechnologies in gene delivery and genetically encoded tools for neuroscience, we introduce a molecular toolkit to characterize the ENS in a robust and efficient manner and modulate the ENS to uncover novel mechanisms by which innervation of the GI mediates host-microbe interactions.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:enteric nervous system, microbiome, nervous system, gastrointestinal tract, intestine, multiple sclerosis
Degree Grantor:California Institute of Technology
Division:Biology and Biological Engineering
Major Option:Biology
Awards:Caltech Center for Environmental Microbial Interactions (CEMI) Fellowship.
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Mazmanian, Sarkis K.
Thesis Committee:
  • Mazmanian, Sarkis K.
  • Gradinaru, Viviana (chair)
  • Lester, Henry A.
  • Bronner, Marianne E.
Defense Date:22 May 2020
Funding AgencyGrant Number
Heritage Medical Research InstituteUNSPECIFIED
Caltech Center for Environmental Microbial Interactions (CEMI)UNSPECIFIED
Emerald FoundationUNSPECIFIED
U.S. Department of Defense (DOD)W81XWH-15-1-0652
Record Number:CaltechTHESIS:04282020-145500248
Persistent URL:
Related URLs:
URLURL TypeDescription 2, Published in PNAS, “Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models.” 3, Published in Cell: Immunity, “The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut.”
Yoo, Bryan B.0000-0003-1450-2696
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13686
Deposited By: Bryan Yoo
Deposited On:01 Jun 2020 22:06
Last Modified:10 Dec 2020 00:13

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