CaltechTHESIS
  A Caltech Library Service

I. The Synthesis of D- and L-Threo- and D- and L-Erythro-α-Amino-β-hydroxy-n-caproic Acids. II. Experiments on the Preparation of α-Aminoalkanesulfonamides. III. The Influence of Nerve Impulse Sequence on the Contractions of Different Crustacean Muscles

Citation

Adams, Robert Train (1950) I. The Synthesis of D- and L-Threo- and D- and L-Erythro-α-Amino-β-hydroxy-n-caproic Acids. II. Experiments on the Preparation of α-Aminoalkanesulfonamides. III. The Influence of Nerve Impulse Sequence on the Contractions of Different Crustacean Muscles. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/BWFC-9S12. https://resolver.caltech.edu/CaltechTHESIS:08292019-160935347

Abstract

The preparation of each of the four optical isomers of α-amino-β-hydroxy-n-caproic acid is described. The configurations of the four optically active amino acids have been deduced on the basis of evidence obtained from the reactions of their N-benzoyl-O-methyl derivatives with p-toluidine in the presence of papain and evidence obtained by oxidative degradation of one of the active α-amino-β-hydroxy-n-caproic acids to an optically active α-hydroxyvaleric acid. The reduction of α-benzamido-β-methoxy-n-caproic acid with lithium aluminum hydride is described.

Experiments directed toward the synthesis of aminomethanesulfonamide and α-aminoethanesulfonamide are reported.

The influence of nerve impulse sequence on the contractions of different crustacean muscles has been investigated by studying the effect of intercalating extra stimuli during stimulation at a low frequency and by studying the effect of changes in the pattern of the stimulating impulses. The effect of impulse-spacing on subsequent facilitation of the contraction has been examined. The results of these investigations are described. The significance of pattern-sensitivity in synaptic structures is discussed.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:Chemistry; Animal Physiology
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Minor Option:Biology
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Niemann, Carl G. (advisor)
  • Weirsma, Cornelis Adrianus Gerrit (advisor)
Thesis Committee:
  • Niemann, Carl G. (chair)
  • Bates, Stuart J.
  • Buchman, Edwin R.
  • Lucas, Howard J.
  • Weirsma, Cornelis Adrianus Gerrit
Defense Date:1950
Additional Information:Thesis title listed in 1950 commencement program varies from actual thesis: I. The Synthesis of D- and L-Threo- and D- and L-Erythro-alpha-Amino-beta-hydroxy-n-caproic Acids. II. Experiments on the Preparation of alpha-Aminoalkanesulfonamides. III. The Influence of Nerve Impulse Sequence on the Contractions of Different Crustacean Muscles
Funders:
Funding AgencyGrant Number
United States Rubber CompanyUNSPECIFIED
Record Number:CaltechTHESIS:08292019-160935347
Persistent URL:https://resolver.caltech.edu/CaltechTHESIS:08292019-160935347
DOI:10.7907/BWFC-9S12
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11770
Collection:CaltechTHESIS
Deposited By: Melissa Ray
Deposited On:04 Sep 2019 23:17
Last Modified:20 Dec 2019 19:36

Thesis Files

[img]
Preview
PDF - Final Version
See Usage Policy.

34MB

Repository Staff Only: item control page