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Development and Dynamics of Microfabricated Enzymatic Biosensors


Adalian, Dvin Artashes-Boghos (2019) Development and Dynamics of Microfabricated Enzymatic Biosensors. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/7GHS-NX49.


We have extended the application of microfabrication techniques to all parts of electrochemical enzymatic sensor processing and characterized the behavior of the resulting new sensor geometries. Improved and parallelized enzyme immobilization techniques utilizing spin coating along with porous sputtered platinum barrier layers are implemented on microfabricated platinum electrodes on silicon wafer substrates as well as on millimeter-scale wireless CMOS potentiostats. Functional biosensor sensitivities and linear ranges were observed with multi-month lifetimes, demonstrating that the enzyme layer fabrication process is compatible with precise and massively parallelized CMOS fabrication, making further progress toward the production of low cost and low-tissue impact fully implantable miniaturized biosensors.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:biosensors, microfabrication, CMOS, enzymatic sensors, spincoating, sputtering, glucose sensing, electrochemical sensors, microdevices
Degree Grantor:California Institute of Technology
Division:Engineering and Applied Science
Major Option:Applied Physics
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Scherer, Axel
Thesis Committee:
  • Daraio, Chiara (chair)
  • Phillips, Robert B.
  • Emami, Azita
  • Scherer, Axel
Defense Date:5 June 2019
Funding AgencyGrant Number
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Record Number:CaltechTHESIS:06102019-031412552
Persistent URL:
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11733
Deposited By: Dvin Adalian
Deposited On:10 Jun 2019 22:59
Last Modified:26 Sep 2023 16:21

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