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Applications of the Enantioselective Allylic Alkylation Toward the Synthesis of Complex Natural Products

Citation

Loskot, Steven Anthony (2019) Applications of the Enantioselective Allylic Alkylation Toward the Synthesis of Complex Natural Products. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/TZHG-9B35. https://resolver.caltech.edu/CaltechTHESIS:05132019-092701701

Abstract

The Stoltz group, and moreover the synthetic community at large, has long been interested in the development of methods for the synthesis of enantioenriched all-carbon quaternary stereocenters. This thesis present three projects all unified by the development and use of the palladium-catalyzed decarboxylative allylic alkylation to synthesize enantioenriched all-carbon quaternary stereocenter containing cyclopentanones as well as the natural product total synthesis.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:Natural Product; Total Synthesis; Asymmetric Allylic Alkylation
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Stoltz, Brian M.
Thesis Committee:
  • Reisman, Sarah E. (chair)
  • Stoltz, Brian M.
  • Grubbs, Robert H.
  • Agapie, Theodor
Defense Date:3 May 2019
Record Number:CaltechTHESIS:05132019-092701701
Persistent URL:https://resolver.caltech.edu/CaltechTHESIS:05132019-092701701
DOI:10.7907/TZHG-9B35
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/9780470682531.pat0858DOIBook section adapted for Chapter 1.
https://doi.org/10.1021/acs.orglett.5b02376DOIArticle adapted for Chapter 2.
https://doi.org/10.1021/jacs.7b05196DOIArticle adapted for Chapter 3.
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11510
Collection:CaltechTHESIS
Deposited By: Steven Loskot
Deposited On:23 May 2019 20:03
Last Modified:21 Dec 2020 21:37

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