Applications of the Enantioselective Allylic Alkylation Toward the Synthesis of Complex Natural Products

Citation

Loskot, Steven Anthony (2019) Applications of the Enantioselective Allylic Alkylation Toward the Synthesis of Complex Natural Products. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/TZHG-9B35. https://resolver.caltech.edu/CaltechTHESIS:05132019-092701701

Abstract

The Stoltz group, and moreover the synthetic community at large, has long been interested in the development of methods for the synthesis of enantioenriched all-carbon quaternary stereocenters. This thesis present three projects all unified by the development and use of the palladium-catalyzed decarboxylative allylic alkylation to synthesize enantioenriched all-carbon quaternary stereocenter containing cyclopentanones as well as the natural product total synthesis.

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