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Harnessing Biological Tools of Protein Transport and Catalysis


McAvoy, Camille Zandra (2018) Harnessing Biological Tools of Protein Transport and Catalysis. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/EXJK-C379.


This work covers two projects related to protein structure and function. The first focuses on studies of chloroplast signal recognition particle 43 (cpSRP43), its interaction with substrate (the light-harvesting, chlorophyll-binding proteins, or LHCP), the role of conformational change in its activity, and the use of cpSRP43 as a tool for handling nonnative proteins. This work utilizes a variety of biochemical and biophysical approaches including light scattering and electron paramagnetic resonance to probe the structure-function relationship of cpSRP43. The second project entails the study of the C-C bond formation mechanism of nitrogenase, a biological nitrogen fixer found in soil microorganisms. Together these projects make for an interesting story of the medicinal and agricultural applications of basic biochemistry.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:Chaperone, enzyme, membrane protein, carbon-carbon bonds
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Rees, Douglas C.
Thesis Committee:
  • Gray, Harry B. (chair)
  • Grubbs, Robert H.
  • Dougherty, Dennis A.
  • Rees, Douglas C.
Defense Date:4 May 2018
Non-Caltech Author Email:camille.mcavoy (AT)
Funding AgencyGrant Number
NIH2 T32 GM 7616-36
Record Number:CaltechTHESIS:05152018-143529378
Persistent URL:
Related URLs:
URLURL TypeDescription adapted for Ch 1. adapted for Ch 2.
McAvoy, Camille Zandra0000-0002-9828-1538
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10892
Deposited By: Camille McAvoy
Deposited On:25 May 2018 18:25
Last Modified:25 May 2021 22:54

Thesis Files

PDF (McAvoy Thesis) - Final Version
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