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Harnessing Biological Tools of Protein Transport and Catalysis

Citation

McAvoy, Camille Zandra (2018) Harnessing Biological Tools of Protein Transport and Catalysis. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/EXJK-C379. https://resolver.caltech.edu/CaltechTHESIS:05152018-143529378

Abstract

This work covers two projects related to protein structure and function. The first focuses on studies of chloroplast signal recognition particle 43 (cpSRP43), its interaction with substrate (the light-harvesting, chlorophyll-binding proteins, or LHCP), the role of conformational change in its activity, and the use of cpSRP43 as a tool for handling nonnative proteins. This work utilizes a variety of biochemical and biophysical approaches including light scattering and electron paramagnetic resonance to probe the structure-function relationship of cpSRP43. The second project entails the study of the C-C bond formation mechanism of nitrogenase, a biological nitrogen fixer found in soil microorganisms. Together these projects make for an interesting story of the medicinal and agricultural applications of basic biochemistry.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:Chaperone, enzyme, membrane protein, carbon-carbon bonds
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Rees, Douglas C.
Thesis Committee:
  • Gray, Harry B. (chair)
  • Grubbs, Robert H.
  • Dougherty, Dennis A.
  • Rees, Douglas C.
Defense Date:4 May 2018
Non-Caltech Author Email:camille.mcavoy (AT) gmail.com
Funders:
Funding AgencyGrant Number
NIH2 T32 GM 7616-36
Record Number:CaltechTHESIS:05152018-143529378
Persistent URL:https://resolver.caltech.edu/CaltechTHESIS:05152018-143529378
DOI:10.7907/EXJK-C379
Related URLs:
URLURL TypeDescription
https://doi.org/10.1074/jbc.RA118.002215DOIArticle adapted for Ch 1.
https://doi.org/10.1073/pnas.1524777113DOIArticle adapted for Ch 2.
ORCID:
AuthorORCID
McAvoy, Camille Zandra0000-0002-9828-1538
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10892
Collection:CaltechTHESIS
Deposited By: Camille McAvoy
Deposited On:25 May 2018 18:25
Last Modified:25 May 2021 22:54

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