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The Total Synthesis of A-23187 and Related Enantioselective Aldol Condensations


Taber, Terry Ray (1981) The Total Synthesis of A-23187 and Related Enantioselective Aldol Condensations. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/xcz4-1016.


A-23187 is a calcium specific ionophore which was isolated from Streptomyces chartreusis. The total synthesis of A-23187 and synthesis of related diacid ionophores are discussed.

[Chemical structure included in scanned thesis' Abstract, p. v.]

The synthetic approach used for A-23187 required stereoselective aldol condensations. In this regard, the development of enantioselective aldol condensations with boron enolates is detailed. The general applications of such condensations are also discussed.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:Chemistry
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Dervan, Peter B.
Thesis Committee:
  • Dervan, Peter B. (chair)
  • Evans, David A.
  • Richards, John H.
  • Dougherty, Dennis A.
Defense Date:8 October 1980
Funding AgencyGrant Number
Record Number:CaltechTHESIS:05072018-142839331
Persistent URL:
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10853
Deposited By: Mel Ray
Deposited On:08 May 2018 17:40
Last Modified:19 Apr 2021 22:39

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