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The Total Synthesis of A-23187 and Related Enantioselective Aldol Condensations

Citation

Taber, Terry Ray (1981) The Total Synthesis of A-23187 and Related Enantioselective Aldol Condensations. Dissertation (Ph.D.), California Institute of Technology. http://resolver.caltech.edu/CaltechTHESIS:05072018-142839331

Abstract

A-23187 is a calcium specific ionophore which was isolated from Streptomyces chartreusis. The total synthesis of A-23187 and synthesis of related diacid ionophores are discussed.

[Chemical structure included in scanned thesis' Abstract, p. v.]

The synthetic approach used for A-23187 required stereoselective aldol condensations. In this regard, the development of enantioselective aldol condensations with boron enolates is detailed. The general applications of such condensations are also discussed.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:Chemistry
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Thesis Availability:Restricted to Caltech community only
Research Advisor(s):
  • Dervan, Peter B.
Thesis Committee:
  • Dervan, Peter B. (chair)
  • Evans, David A.
  • Richards, John H.
  • Dougherty, Dennis A.
Defense Date:8 October 1980
Funders:
Funding AgencyGrant Number
National Institutes of Health (NIH)UNSPECIFIED
California Institute of TechnologyUNSPECIFIED
Record Number:CaltechTHESIS:05072018-142839331
Persistent URL:http://resolver.caltech.edu/CaltechTHESIS:05072018-142839331
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10853
Collection:CaltechTHESIS
Deposited By: Melissa Ray
Deposited On:08 May 2018 17:40
Last Modified:17 Aug 2018 01:15

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