A Caltech Library Service

Studies on a Cytochrome Destroying System in Neurospora


Herzenberg, Leonard Arthur (1956) Studies on a Cytochrome Destroying System in Neurospora. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/X9PN-W252.


The results of investigations on a cytochrome destroying system in Neurospora are presented. It is shown that the destruction is complex and dependent on the action of several enzymes as well-as non-catalyzed reactions. Poky particles exhibit a rapid and extensive hydrolysis of their own and added proteins whereas fast poky and wild-type particles do so to a much smaller extent. When cytochrome c is added to poky particles or particle-derived preparations, heme-peptides are produced. Several heme-peptides are partially characterized. Evidence is presented which suggests that poky particles, succinate and cytochrome c, when incubated together in air, produce a verdohemochrome. An ether soluble substance is found in poky and fast poky particles which combines with cytochrome c so that the iron is not reducible by ascorbate and the heme group is destroyed on reduction by hydrosulfite and reoxidation by oxygen. Purification of this substance and some of its chemical properties are described. It has been named "pokonic acid."

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:(Biochemistry and Immunology)
Degree Grantor:California Institute of Technology
Major Option:Biochemistry
Minor Option:Immunology
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Mitchell, Herschel K.
Thesis Committee:
  • Unknown, Unknown
Defense Date:1 January 1956
Record Number:CaltechETD:etd-03232004-140910
Persistent URL:
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1066
Deposited By: Imported from ETD-db
Deposited On:23 Mar 2004
Last Modified:13 Jul 2023 18:23

Thesis Files

PDF (Herzenberg_la_1956.pdf) - Final Version
See Usage Policy.


Repository Staff Only: item control page