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A Current Look at the Biological Basis of Antibody Diversity and Specificity


Barstad, Paul Arlyn (1975) A Current Look at the Biological Basis of Antibody Diversity and Specificity. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/0931-D337.


Using automated protein sequence analysis of BALB/c myeloma proteins, the genetic basis for antibody specificity and diversity is investigated. Studies on the N-terminal regions of the heavy chains from these immunoglobulins reveal that a large amount of diversity must exist in the VH regions. Examination of the heavy and light chain sequences from myeloma proteins with hapten-binding activities indicates that the heavy chain variable region sequence correlates closely with all the specificities of intact molecules. The light chain appears to be less restricted in some specificities, however. The relevance of these data to the proposed mechanisms of antibody diversity is discussed.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:Biochemistry
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Biochemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Hood, Leroy E.
Thesis Committee:
  • Unknown, Unknown
Defense Date:18 April 1975
Record Number:CaltechTHESIS:12132017-081719269
Persistent URL:
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10604
Deposited By: Benjamin Perez
Deposited On:13 Dec 2017 17:18
Last Modified:21 Dec 2019 02:51

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