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I. Hapten Inhibition Studies with a Series of Local Anesthetics Derived from Piperidino Alcohols. II. The Incorporation of C^(14)-Carboxyl-Labeled Leucine by Serum Proteins

Citation

Bulman, Norman (1952) I. Hapten Inhibition Studies with a Series of Local Anesthetics Derived from Piperidino Alcohols. II. The Incorporation of C^(14)-Carboxyl-Labeled Leucine by Serum Proteins. Dissertation (Ph.D.), California Institute of Technology. http://resolver.caltech.edu/CaltechTHESIS:09272017-105740469

Abstract

Part I

Rabbit antibodies specific for the 3-(2-methyl-piperidino)propyl-p-aminobenzoate group have been prepared and the inhibition of precipitation of these antibodies has been studied. It was found that a series of local anesthetics derived from piperidino alcohols were effective inhibitors of precipitation in this system. Reasonable explanations of the serological properties of these drugs have been given but it has not been found possible to establish any relation between their serological properties and their pharmacological properties.

Part II

C14-carboxyl-labeled leucine has been administered to immunized rabbits. While receiving the labeled amino acid they also received intravenous injections of different antibody solutions. It was found that the normal constituents of the serum incorporated the radioactivity to any marked extent or else did so only upon the loss of their specific antibody characteristics.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:Chemistry
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Campbell, Dan Hampton (advisor)
  • Pauling, Linus (co-advisor)
Thesis Committee:
  • Unknown, Unknown
Defense Date:1 January 1952
Record Number:CaltechTHESIS:09272017-105740469
Persistent URL:http://resolver.caltech.edu/CaltechTHESIS:09272017-105740469
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10462
Collection:CaltechTHESIS
Deposited By: Benjamin Perez
Deposited On:27 Sep 2017 20:59
Last Modified:27 Sep 2017 20:59

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