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Biochemistry and Genetics of Canavanine Resistance in Neurospora


Logan, James Barrie (1969) Biochemistry and Genetics of Canavanine Resistance in Neurospora. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/2j3p-es09.


The pattern of inheritance of resistance to growth inhibition by canavanine in Neurospora crassa is shown to result from interactions between a major gene and several modifiers. The major gene controls the production of a constitutive enzyme that destroys canavanine. The modifiers affect the rate of uptake of the analog from the medium. Strains which lack the enzyme activity are canavanine sensitive; strains which possess it are resistant, but the level of resistance is dependent on the rate of uptake.

The canavanine degrading enzyme was partially purified and its properties studied. The detoxification reaction was shown to be a cleavage of canavanine yielding hydroxyguanidine.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:(Biochemistry and Chemistry)
Degree Grantor:California Institute of Technology
Major Option:Biochemistry
Minor Option:Chemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Horowitz, Norman Harold
Thesis Committee:
  • Unknown, Unknown
Defense Date:24 February 1969
Funding AgencyGrant Number
United States Public Health ServiceUNSPECIFIED
Record Number:CaltechTHESIS:06022017-085722120
Persistent URL:
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10251
Deposited By: Benjamin Perez
Deposited On:02 Jun 2017 17:12
Last Modified:29 Apr 2024 22:43

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