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An Optofluidic Ring Resonator Platform for Rapid and Robust Sensing

Citation

Popescu, Paula Flor (2017) An Optofluidic Ring Resonator Platform for Rapid and Robust Sensing. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/Z9H41PFQ. http://resolver.caltech.edu/CaltechTHESIS:12012016-194127904

Abstract

Ring resonators show great potential as sensitive optical detectors for studies of biomolecular interactions, drug screening, and point-of-care diagnostics. They are sensitive to minute changes in the refractive index of the surrounding medium, which enables them to detect and quantify sub-femtomolar concentrations of target molecules. This thesis investigates the advantages of an optofluidic ring resonator platform that employs a differential measurement scheme for reducing environmental noise due to temperature and pressure fluctuations. Through simulations and experiments, I determine the sensitivity of the platform to changes in the target analyte concentration and to environmental noise, and demonstrate the benefits of employing a second, reference, ring resonator.

A crucial step in achieving versatile biosensing platforms is the integration of the high sensitivity resonators into platforms with short assay times and robust chemical functionalization. I focus on the development of robust chemistry protocols for depositing linker silane layers for biomolecular interaction studies. Moreover, since the fluid handling scheme strongly influences the response time of the platform, I design and test two fluidic platforms integrated with elastomeric valves that show excellent response times. To further increase the response time of the sensing platform, I explore the effects of a patterned channel geometry on the enhancement of mass transport to the sensor in low Reynolds number flows.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:ring resonators, whispering gallery mode sensors, biosensing, microfluidics
Degree Grantor:California Institute of Technology
Division:Engineering and Applied Science
Major Option:Applied Physics
Thesis Availability:Restricted to Caltech community only
Research Advisor(s):
  • Flagan, Richard C.
Thesis Committee:
  • Yariv, Amnon (chair)
  • Faraon, Andrei
  • Schwab, Keith C.
  • Flagan, Richard C.
Defense Date:23 September 2016
Funders:
Funding AgencyGrant Number
NSF1152623
Record Number:CaltechTHESIS:12012016-194127904
Persistent URL:http://resolver.caltech.edu/CaltechTHESIS:12012016-194127904
DOI:10.7907/Z9H41PFQ
Related URLs:
URLURL TypeDescription
https://doi.org/10.1364/OL.40.004106DOIArticle related to Ch. 2
https://doi.org/10.1364/CLEO_SI.2015.STu4K.7DOIArticle related to Ch. 2
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:9989
Collection:CaltechTHESIS
Deposited By: Paula Popescu
Deposited On:09 Dec 2016 21:33
Last Modified:15 Feb 2017 16:34

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