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The synthesis of O-methyl-N-acetyl-L-tyrosine

Citation

Brady, William Thomas (1957) The synthesis of O-methyl-N-acetyl-L-tyrosine. Master's thesis, California Institute of Technology. http://resolver.caltech.edu/CaltechTHESIS:04292010-095951946

Abstract

An efficient method of preparing N-acetyl-L-tyrosine methyl ester is described. This compound has been converted to the optically pure O-methyl derivative by reaction with diazomethane. The saponification of N-acetyl-L-tyrosine methyl ester is a more convenient rout to N-acetyl-L-tyrosine than the direct acetylation of L-tyrosine. N-acetyl-L-tyrosine can be converted to optically pure O-methylN-acetyl-L-tyrosine via the Williamson synthesis. The preparation of several other derivatives of L- tyrosine is also described.

Item Type:Thesis (Master's thesis)
Subject Keywords:Chemistry
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Niemann, Carl G.
Thesis Committee:
  • Unknown, Unknown
Defense Date:1 January 1957
Record Number:CaltechTHESIS:04292010-095951946
Persistent URL:http://resolver.caltech.edu/CaltechTHESIS:04292010-095951946
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:5752
Collection:CaltechTHESIS
Deposited By: Tony Diaz
Deposited On:07 Jul 2010 15:21
Last Modified:26 Dec 2012 03:24

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