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An in vitro study of the ionophore properties of the acetylcholine receptor in Torpedo Californica membrane fragments

Citation

Miller, Donald (1976) An in vitro study of the ionophore properties of the acetylcholine receptor in Torpedo Californica membrane fragments. Master's thesis, California Institute of Technology. http://resolver.caltech.edu/CaltechTHESIS:03292010-091454086

Abstract

An in vitro system for studying the ionophore properties of the nicotinic acetylcholine receptor from the electric organs of Torpedo californica was developed. Efflux of ^(22)Na^+ from microsacs rich in AcChR was studied as a function of the addition of various agonists and antagonists to the medium. In the presence of agonists increased rates of efflux of ^(22)Na^+ occurred, and this affect was abolished in the presence of antagonists. The in vitro response to varying concentrations of carbamylcholine was determined. The desensitization phenomenon occurring in vivo was also found to occur in vitro.

Item Type:Thesis (Master's thesis)
Subject Keywords:Chemsitry
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Raftery, Michael A.
Thesis Committee:
  • Unknown, Unknown
Defense Date:1 June 1976
Record Number:CaltechTHESIS:03292010-091454086
Persistent URL:http://resolver.caltech.edu/CaltechTHESIS:03292010-091454086
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:5643
Collection:CaltechTHESIS
Deposited By: Tony Diaz
Deposited On:15 Apr 2010 17:55
Last Modified:26 Dec 2012 03:23

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