CaltechTHESIS
  A Caltech Library Service

The preparation and properties of large lecithin bilayer vesicles

Citation

Hurley, John N. (1974) The preparation and properties of large lecithin bilayer vesicles. Master's thesis, California Institute of Technology. http://resolver.caltech.edu/CaltechTHESIS:11132009-091109533

Abstract

Sonicated lecithin vesicles of an "average" diameter of 1200 Å were prepared. PMR studies show a higher phase transition temperature than that found for small (300 - 500 Å) vesicles. Osmotic pressure collapses the vesicle but does not change the PMR linewidth. This differs from the effect found in small vesicles. Upon addition of a cyclic polyether (cyclohexyl-15-crown-5) to a solution of large vesicles, the water diffusion rate is found to increase by a factor of 5 to 10. The internal water volume also increases significantly, suggesting that the crown compound is incorporated into the bilayer.

Item Type:Thesis (Master's thesis)
Subject Keywords:Chemistry
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Chan, Sunney I.
Thesis Committee:
  • Unknown, Unknown
Defense Date:September 1973
Record Number:CaltechTHESIS:11132009-091109533
Persistent URL:http://resolver.caltech.edu/CaltechTHESIS:11132009-091109533
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:5373
Collection:CaltechTHESIS
Deposited By: Tony Diaz
Deposited On:17 Nov 2009 21:59
Last Modified:26 Dec 2012 03:18

Thesis Files

[img]
Preview
PDF - Final Version
See Usage Policy.

513Kb

Repository Staff Only: item control page