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Electrical detection of DNA binding proteins

Citation

Gorodetsky, Alon A. (2009) Electrical detection of DNA binding proteins. Dissertation (Ph.D.), California Institute of Technology. http://resolver.caltech.edu/CaltechETD:etd-12102008-101354

Abstract

The base pair stack of double helical DNA has proven to be an effective medium for charge transport. The π-stacked DNA base pairs can mediate charge transport (CT) chemistry over distances as long as 20 nm, and the reaction is exquisitely sensitive to DNA sequence-dependent conformation and dynamics. This sensitivity to perturbations in DNA structure and base pair stacking makes DNA-mediated charge transport chemistry an ideal methodology for the electrical detection of base mismatches, lesions, and protein binding. Efforts toward expanding the scope of electrochemistry at DNA-modified surfaces for biosensing applications are presented here.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:DNA; electrochemistry; monolayers; proteins; self-assembly
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Barton, Jacqueline K.
Thesis Committee:
  • Heath, James R. (chair)
  • Gray, Harry B.
  • Barton, Jacqueline K.
  • Lewis, Nathan Saul
Defense Date:1 December 2008
Record Number:CaltechETD:etd-12102008-101354
Persistent URL:http://resolver.caltech.edu/CaltechETD:etd-12102008-101354
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:5261
Collection:CaltechTHESIS
Deposited By: Imported from ETD-db
Deposited On:03 Jun 2009
Last Modified:07 Feb 2014 18:34

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