The behavior of an unstable ring chromosome in Drosophila melanogaster

Citation

Hinton, Claude Willey (1954) The behavior of an unstable ring chromosome in Drosophila melanogaster. Dissertation (Ph.D.), California Institute of Technology. http://resolver.caltech.edu/CaltechETD:etd-12152003-115148

Abstract

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The behavior of "Catcheside's ring," an unstable closed-X chromosome [...] of Drosophila melanogaster, has been analyzed with the purpose of identifying the factors controlling the variable-level of [...] instability and of determining the mechanism of [...] elimination. The Y chromosome and the structure of the homologous rod-X chromosome were shown to have no influence on the frequency of [...] elimination. Since no segregating autosomal or sex-linked modifiers could be detected, the primary control of [...] instability must be limited to the [...] chromosome itself. The behavior of unstable small duplications derive from the [...] chromosome suggests that the locus of [...] instability must be in or near the [...] centromere region.

The frequency of [...] elimination is directly related to developmental temperature and to age of maternal [...] parents. Certain preliminary results incurred the speculation that a cytoplasmic factor is operative in [...] elimination.

Either anaphase lagging or the production of anaphase bridges by the [...] chromosome will account for its loss. The occurrence of [...] derivatives, deficient for either extensive or small euchromatic segments, suggests that anaphase bridges composed of continuous dicentric rings may be formed; however, such bridges do not necessarily constitute the exclusive means of elimination.

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