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The structures of phytotoxic compounds from Thamnosma Montana. The action of phytotoxic compounds on plants. Preparation and reactions of S-phenylthiolcarbamates. Studies on the synthesis of actidione

Citation

Crosby, Donald Gibson (1954) The structures of phytotoxic compounds from Thamnosma Montana. The action of phytotoxic compounds on plants. Preparation and reactions of S-phenylthiolcarbamates. Studies on the synthesis of actidione. Dissertation (Ph.D.), California Institute of Technology. http://resolver.caltech.edu/CaltechETD:etd-12042003-095430

Abstract

The chemistry of the three phytotoxic compounds isolated from Thamnosma montana by E.L. Bennett in 1949 has been studied, and two of the substances have been identified as the known furocoumarins isopimpinellin and byakangelicin. Degradation and partial synthesis of the third compound have shown that it is also a furocoumarin, and have indicated its probable structure.

The effects of several naturally-occurring phytotoxic substances on plants have been observed under controlled conditions, and have been compared with the effects noted in nature. The mechanism of the toxic action is still ambiguous.

Convenient methods for the synthesis of S-substituted thiolcarbamates have been found, and the scope and limitations of their reactions with primary and secondary amines, amides, and hydrazines to produce ureas, acylureas, and semicarbazides, respectively, have been determined. The mechanism of the general reaction and its application to the identification of organic compounds also have been considered.

Attempts have been made to synthesize the antibiotic substance "Actidione" by four different routes, and although this end has not been achieved, much groundwork has been laid for the eventual preparation of the compound.

Item Type:Thesis (Dissertation (Ph.D.))
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Niemann, Carl G.
Thesis Committee:
  • Unknown, Unknown
Defense Date:1 January 1954
Record Number:CaltechETD:etd-12042003-095430
Persistent URL:http://resolver.caltech.edu/CaltechETD:etd-12042003-095430
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:4760
Collection:CaltechTHESIS
Deposited By: Imported from ETD-db
Deposited On:09 Dec 2003
Last Modified:26 Dec 2012 03:11

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