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Immunoglobulins: structure, genetics, and evolution


Hood, Leroy E. (1968) Immunoglobulins: structure, genetics, and evolution. Dissertation (Ph.D.), California Institute of Technology.


The immune system is capable of generating an immense number of different antibody molecules. The nature of the genetic machinery responsible for this diversity has been studied by selective amino acid sequence analysis of homogeneous immunoglobulin light chains (derived from myeloma tumors). The evolution of the immune system has also been examined through chemical studies of normal pooled light chains derived from various mammalian and avian species. These studies place constraints on proposed genetic mechanisms for antibody diversity. The theories, the structural constraints, and the evolutionary implications of these observations are discussed.

Item Type:Thesis (Dissertation (Ph.D.))
Degree Grantor:California Institute of Technology
Major Option:Biology
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Dreyer, William J.
Thesis Committee:
  • Unknown, Unknown
Defense Date:29 November 1967
Record Number:CaltechETD:etd-09162004-110314
Persistent URL:
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:3561
Deposited By: Imported from ETD-db
Deposited On:17 Sep 2004
Last Modified:26 Dec 2012 03:00

Thesis Files

PDF (Hood_le_1968.pdf) - Final Version
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