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I. The synthesis of potential antimalarials : A. Carbinolamines related to quinine; B. Sulfonamides. II. The resolution of 3-fluoro-dl-tyrosine, and the determination of the acute toxicity of the optically active isomers. III. The synthesis of p-arsono-dl-phenylalanine. IV. A study of the proteins in some invertebrate body fluids

Citation

Rapport, Maurice M. (1945) I. The synthesis of potential antimalarials : A. Carbinolamines related to quinine; B. Sulfonamides. II. The resolution of 3-fluoro-dl-tyrosine, and the determination of the acute toxicity of the optically active isomers. III. The synthesis of p-arsono-dl-phenylalanine. IV. A study of the proteins in some invertebrate body fluids. Dissertation (Ph.D.), California Institute of Technology. http://resolver.caltech.edu/CaltechETD:etd-09122006-084203

Abstract

Part I: The synthesis of two series of compounds, benzenesulfonanilides and carbinolamines related to quinine, are described. These compounds were prepared as potential antimalarials.

Part II: The enzymatic resolution of N-benzoyl 3-fluoro-dl-tyrosine and the preparation of 3-fluoro-D- and L-tyrosine are described. A study of the acute toxicity of the optical isomers is also reported.

Part III: The synthesis of p-arsono-N-acetylphenylalanine is described.

Part IV: The chemical fractionation of the protein constituents of Panulirus Interruptus (spiny lobster) blood was repeated, and an electrophoretic study of the fractions, confirming the presence of at least three separate proteins, is described. Preliminary fractionations of the body fluids of Cancer Anthonyi (crab), Stichopus Californicus (sea cucumber), and Halitotis Fulgens (green abalone) are also reported.

Item Type:Thesis (Dissertation (Ph.D.))
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Koepfli, Joseph Blake
Thesis Committee:
  • Koepfli, Joseph Blake (chair)
  • Niemann, Carl G.
  • Campbell, Dan Hampton
Defense Date:1 January 1945
Record Number:CaltechETD:etd-09122006-084203
Persistent URL:http://resolver.caltech.edu/CaltechETD:etd-09122006-084203
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:3495
Collection:CaltechTHESIS
Deposited By: Imported from ETD-db
Deposited On:13 Sep 2006
Last Modified:26 Dec 2012 03:00

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