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Studies on RNA metabolism in HeLa mitochondria


Gelfand, Robert Allen (1980) Studies on RNA metabolism in HeLa mitochondria. Dissertation (Ph.D.), California Institute of Technology.


The metabolism of mitochondrial ribonucleic acid was studied in the human cell line HeLa. Studies of labeling kinetics show that polyadenylated mitochondrial RNA species are turned over with half-lives ranging from a few minutes to about two hours.

Several giant RNA species transcribed from the mitochondrial DNA light strand were studied. They range in size from approximately 25% to 60% of the length of the mitochondrial genome and overlap in their mapping locations.

The kinetics of labeling of mitochondrial polyadenylic acid not covalently linked to larger RNA molecules was studied. This "free" polyadenylic acid is not derived from the breakdown of larger polyadenylated RNA molecules and may be a precursor to polyadenylic acid covalently linked to messenger RNA molecules.

Item Type:Thesis (Dissertation (Ph.D.))
Degree Grantor:California Institute of Technology
Major Option:Biology
Thesis Availability:Restricted to Caltech community only
Research Advisor(s):
  • Unknown, Unknown
Thesis Committee:
  • Unknown, Unknown
Defense Date:7 January 1980
Record Number:CaltechETD:etd-08042006-124851
Persistent URL:
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:3007
Deposited By: Imported from ETD-db
Deposited On:23 Aug 2006
Last Modified:26 Dec 2012 02:56

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