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I. Studies on mixed anhydride systems. II. Studies of the alpha chymotrypsin catalyzed hydrolysis of specific substrates

Citation

Mower, Howard F. (1956) I. Studies on mixed anhydride systems. II. Studies of the alpha chymotrypsin catalyzed hydrolysis of specific substrates. Dissertation (Ph.D.), California Institute of Technology. http://resolver.caltech.edu/CaltechETD:etd-06162004-132607

Abstract

The synthesis and purification of p-nitrobenzoic-acetic mixed anhydride, p-methoxybenzoic-acetic mixed anhydride and benzoic-acetic mixed anhydride is described. The thermodynamic constants for the disproportionation reaction have been determined. A mechanism for this reaction is discussed. Measurements of the interaction of acetic and benzoic acids with the acetic-benzoic anhydride system have been made.

The cleavage of the mixed anhydrides with nucleophilic agents is described.

The synthesis of the following compounds is described: N-trimethylacetyl-L-tyrosinhydrazide, N-dichloroacetyl-L-tyrosinhydrazide, N-formyl-L-tyrosinhydrazide, N-trichloroacetyl-L-tyrosinamide and N-acetyl-L-cysteic acid carboxylamide. The kinetic constants for the [alpha] chymotrypsin hydrolysis of these substances are reported.

Item Type:Thesis (Dissertation (Ph.D.))
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Niemann, Carl G.
Thesis Committee:
  • Unknown, Unknown
Defense Date:1 January 1956
Record Number:CaltechETD:etd-06162004-132607
Persistent URL:http://resolver.caltech.edu/CaltechETD:etd-06162004-132607
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:2615
Collection:CaltechTHESIS
Deposited By: Imported from ETD-db
Deposited On:17 Jun 2004
Last Modified:26 Dec 2012 02:53

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