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I. Studies on Mixed Anhydride Systems. II. Studies of the Alpha-Chymotrypsin Catalyzed Hydrolysis of Specific Substrates

Citation

Mower, Howard Frederick (1956) I. Studies on Mixed Anhydride Systems. II. Studies of the Alpha-Chymotrypsin Catalyzed Hydrolysis of Specific Substrates. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/031V-1769. https://resolver.caltech.edu/CaltechETD:etd-06162004-132607

Abstract

The synthesis and purification of p-nitrobenzoic-acetic mixed anhydride, p-methoxybenzoic-acetic mixed anhydride and benzoic-acetic mixed anhydride is described. The thermodynamic constants for the disproportionation reaction have been determined. A mechanism for this reaction is discussed. Measurements of the interaction of acetic and benzoic acids with the acetic-benzoic anhydride system have been made. The cleavage of the mixed anhydrides with nucleophilic agents is described. The synthesis of the following compounds is described: N-trimethylacetyl-L-tyrosinhydrazide, N-dichloroacetyl-L-tyrosinhydrazide, N-formyl-L-tyrosinhydrazide, N-trichloroacetyl-L-tyrosinamide and N-acetyl-L-cysteic acid carboxylamide. The kinetic constants for the [alpha] chymotrypsin hydrolysis of these substances are reported.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:(Chemistry and Chemical Engineering)
Degree Grantor:California Institute of Technology
Division:Chemistry and Chemical Engineering
Major Option:Chemistry
Minor Option:Chemical Engineering
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Niemann, Carl G.
Thesis Committee:
  • Unknown, Unknown
Defense Date:1 January 1956
Record Number:CaltechETD:etd-06162004-132607
Persistent URL:https://resolver.caltech.edu/CaltechETD:etd-06162004-132607
DOI:10.7907/031V-1769
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:2615
Collection:CaltechTHESIS
Deposited By: Imported from ETD-db
Deposited On:17 Jun 2004
Last Modified:13 Jul 2023 22:58

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