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Studies of rearrangements involving heterochromatin in Drosophila melanogaster. I. A proof of variegated-type position effect at the white locus. II. A study of the heterochromatin of chromosome IV

Citation

Judd, Burke Haycock (1954) Studies of rearrangements involving heterochromatin in Drosophila melanogaster. I. A proof of variegated-type position effect at the white locus. II. A study of the heterochromatin of chromosome IV. Dissertation (Ph.D.), California Institute of Technology. http://resolver.caltech.edu/CaltechETD:etd-01152004-095338

Abstract

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The X-IV translocation, [...], is shown to contain the wild-type allele, [...], at the white locus. This [...] has been replaced with a mutant gene, w, and a comparison of R([...])/w with R(w)/w[...] shows the former to give a variegated white phenotype while the latter is completely wild-type. It is concluded that the white variegation is due to an instability in the action of [...] when it is located in the rearranged chromosome.

Cold temperature enhances variegation particularly when applied during the embryonic stages of development. A less sensitive period is found to exist during the pupal stages. These facts indicate the white gene is active during more than a single period of development.

Twelve duplication-deficiency types have been obtained by combining the left and right parts of four X-IV translocations. Tests for survival of these combinations in the haplo-IV condition give somewhat contradictory results. These results are discussed and a possible order for the fourth chromosome translocation breaks is given.

Item Type:Thesis (Dissertation (Ph.D.))
Degree Grantor:California Institute of Technology
Division:Biology
Major Option:Biology
Thesis Availability:Public (worldwide access)
Research Advisor(s):
  • Lewis, Edward B.
Thesis Committee:
  • Unknown, Unknown
Defense Date:1 January 1954
Record Number:CaltechETD:etd-01152004-095338
Persistent URL:http://resolver.caltech.edu/CaltechETD:etd-01152004-095338
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:182
Collection:CaltechTHESIS
Deposited By: Imported from ETD-db
Deposited On:28 Jan 2004
Last Modified:26 Dec 2012 02:27

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