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Compact Microscope System for Biomedical Applications

Citation

Kim, Jinho (2017) Compact Microscope System for Biomedical Applications. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/Z9H9937R. http://resolver.caltech.edu/CaltechTHESIS:04262017-114441886

Abstract

Demands for an imaging system which has high space-bandwidth product (SBP) are increasing in modern biomedical research as the amount of information to be dealt with is increasing. However, conventional microscopy has a limited SBP of about 10 mega pixels, and as such if a user wants an image in high resolution, the field of view (FOV) of the image is reduced, or if a wide FOV is necessary, the user needs to give up the resolution of image. A common way of overcoming this SBP limit in the conventional microscopy is to use mechanical moving stages and scan through wide sample area, however, it is time consuming to image large area using a high numerical aperture (NA) objective lens. This thesis presents compact imaging systems based on Fourier ptychographic microscopy for biomedical applications which are able to increase SBP without having any mechanical moving parts: one imaging system for an incubator embedded imaging system to be used in in-vitro cell culture monitoring, and the other for a high throughput 96 well plate imaging system for fast drug screening.

Item Type:Thesis (Dissertation (Ph.D.))
Subject Keywords:Compact, Microscope, Fourier, Ptychography
Degree Grantor:California Institute of Technology
Division:Engineering and Applied Science
Major Option:Electrical Engineering
Thesis Availability:Restricted to Caltech community only
Research Advisor(s):
  • Yang, Changhuei
Thesis Committee:
  • Yang, Changhuei (chair)
  • Tai, Yu-Chong
  • Vaidyanathan, P. P.
  • Lester, Henry A.
  • Elowitz, Michael B.
Defense Date:15 May 2017
Non-Caltech Author Email:pluto0123 (AT) gmail.com
Record Number:CaltechTHESIS:04262017-114441886
Persistent URL:http://resolver.caltech.edu/CaltechTHESIS:04262017-114441886
DOI:10.7907/Z9H9937R
Default Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10146
Collection:CaltechTHESIS
Deposited By: Jinho Kim
Deposited On:07 Jun 2017 20:56
Last Modified:07 Jun 2017 20:56

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